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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50119476
Substrate
n/a
Meas. Tech.
ChEMBL_2585 (CHEMBL617606)
IC50
142±n/a nM
Citation
 Asproni, B; Pau, A; Bitti, M; Melosu, M; Cerri, R; Dazzi, L; Seu, E; Maciocco, E; Sanna, E; Busonero, F; Talani, G; Pusceddu, L; Altomare, C; Trapani, G; Biggio, G Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors. J Med Chem 45:4655-68 (2002) [PubMed]
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM50119476
Synonyms:
1-(2-Chloro-phenyl)-4-(1,2-diphenyl-1H-imidazol-4-ylmethyl)-piperazine | CHEMBL344084
Type:
Small organic molecule
Emp. Form.:
C26H25ClN4
Mol. Mass.:
428.957
SMILES:
Clc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: