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Target
D(2) dopamine receptor
Ligand
BDBM50119464
Substrate
n/a
Meas. Tech.
ChEMBL_61446 (CHEMBL670672)
IC50
167.5±n/a nM
Citation
 Asproni, B; Pau, A; Bitti, M; Melosu, M; Cerri, R; Dazzi, L; Seu, E; Maciocco, E; Sanna, E; Busonero, F; Talani, G; Pusceddu, L; Altomare, C; Trapani, G; Biggio, G Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors. J Med Chem 45:4655-68 (2002) [PubMed]
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50119464
Synonyms:
1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(3-methoxy-phenyl)-piperazine | CHEMBL344202
Type:
Small organic molecule
Emp. Form.:
C27H28N4O
Mol. Mass.:
424.5374
SMILES:
COc1cccc(c1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Structure:
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