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Target
Cytochrome P450 2D26
Ligand
BDBM50246936
Substrate
n/a
Meas. Tech.
ChEMBL_51710 (CHEMBL665725)
IC50
350±n/a nM
Citation
 Venhorst, J; ter Laak, AM; Commandeur, JN; Funae, Y; Hiroi, T; Vermeulen, NP Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. J Med Chem 46:74-86 (2002) [PubMed]  Article
Target
Name:
Cytochrome P450 2D26
Synonyms:
CP2DQ_RAT | CYPIID26 | Cyp2d-26 | Cyp2d2 | Cyp2d26 | Cytochrome P450 2D2 | Cytochrome P450 2D26 | Debrisoquine 4-hydroxylase | P450-CMF2 | P450-DB2
Type:
PROTEIN
Mol. Mass.:
56689.75
Organism:
Rattus norvegicus
Description:
ChEMBL_51710
Residue:
500
Sequence:
MGLLIGDDLWAVVIFTAIFLLLVDLVHRHKFWTAHYPPGPVPLPGLGNLLQVDFENMPYSLYKLRSRYGDVFSLQIAWKPVVVINGLKAVRELLVTYGEDTADRPLLPIYNHLGYGNKSKGVVLAPYGPEWREQRRFSVSTLRDFGVGKKSLEQWVTEEAGHLCDTFAKEAEHPFNPSILLSKAVSNVIASLVYARRFEYEDPFFNRMLKTLKESFGEDTGFMAEVLNAIPILLQIPGLPGKVFPKLNSFIALVDKMLIEHKKSWDPAQPPRDMTDAFLAEMQKAKGNPESSFNDENLRLVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHEEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADIVPTNIPHMTSRDIKFQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVLAGRPRPSTHGVYALPVTPQPYQLCAVAR
  
Inhibitor
Name:
BDBM50246936
Synonyms:
(-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL | CHEMBL452861 | PROPRANOLOL | S-(-)-propanolol | [2-Hydroxy-3-(naphthalen-1-yloxy)-propyl]-isopropyl-ammonium((-)-propranolol)
Type:
Small organic molecule
Emp. Form.:
C16H21NO2
Mol. Mass.:
259.3434
SMILES:
CC(C)NC[C@H](O)COc1cccc2ccccc12 |r|
Structure:
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