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Target
Neprilysin
Ligand
BDBM50130714
Substrate
n/a
Meas. Tech.
ChEMBL_144608 (CHEMBL751027)
IC50
2000000±n/a nM
Citation
 Filimonov, DA; Gomazkov, OA; Lagunin, AA; Gureeva, TA; Dilakyan, EA; Kugaevskaya, EV; Elisseeva, YE; Solovyeva, NI; Poroikov, VV Computer-aided selection of potential antihypertensive compounds with dual mechanism of action. J Med Chem 46:3326-32 (2003) [PubMed]  Article
Target
Name:
Neprilysin
Synonyms:
Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11
Type:
Protein
Mol. Mass.:
85789.59
Organism:
Rattus norvegicus (Rat)
Description:
P07861
Residue:
750
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
  
Inhibitor
Name:
BDBM50130714
Synonyms:
1-(3-Mercapto-propionyl)-6-methyl-piperidine-2-carboxylic acid | CHEMBL331575
Type:
Small organic molecule
Emp. Form.:
C10H17NO3S
Mol. Mass.:
231.312
SMILES:
CC1CCCC(N1C(=O)CCS)C(O)=O
Structure:
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