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Target
NH(3)-dependent NAD(+) synthetase
Ligand
BDBM50366389
Substrate
n/a
Meas. Tech.
ChEMBL_141613 (CHEMBL747929)
IC50
>1000±n/a nM
Citation
 Velu, SE; Cristofoli, WA; Garcia, GJ; Brouillette, CG; Pierson, MC; Luan, CH; DeLucas, LJ; Brouillette, WJ Tethered dimers as NAD synthetase inhibitors with antibacterial activity. J Med Chem 46:3371-81 (2003) [PubMed]  Article
Target
Name:
NH(3)-dependent NAD(+) synthetase
Synonyms:
GSP38 | General stress protein 38 | NADE_BACSU | Spore outgrowth factor B | Sporulation protein outB | nadE | outB
Type:
PROTEIN
Mol. Mass.:
30386.77
Organism:
Bacillus subtilis
Description:
ChEMBL_141613
Residue:
272
Sequence:
MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVLGISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDKSWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDHAAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQQSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK
  
Inhibitor
Name:
BDBM50366389
Synonyms:
GENTAMICIN
Type:
Small organic molecule
Emp. Form.:
C21H43N5O7
Mol. Mass.:
477.5954
SMILES:
CN[C@H](C)[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1 |r|
Structure:
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