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Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50132135
Substrate
n/a
Meas. Tech.
ChEMBL_144336 (CHEMBL751847)
Ki
>100000±n/a nM
Citation
 van Herk, T; Brussee, J; van den Nieuwendijk, AM; van der Klein, PA; IJzerman, AP; Stannek, C; Burmeister, A; Lorenzen, A Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem 46:3945-51 (2003) [PubMed]  Article
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
Gpr109 | Gpr109a | Gpr109b | HCAR2_RAT | HM74 nicotinic acid GPCR | Hcar2 | Niacr1 | Pumag
Type:
PROTEIN
Mol. Mass.:
41476.06
Organism:
Rattus norvegicus
Description:
ChEMBL_820675
Residue:
360
Sequence:
MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
  
Inhibitor
Name:
BDBM50132135
Synonyms:
4,6-Dihydro-1H-furo[3,4-c]pyrazole-3-carboxylic acid | 4,6-dihydro-2H-furo[3,4-c]pyrazole-3-carboxylic acid | CHEMBL338071
Type:
Small organic molecule
Emp. Form.:
C6H6N2O3
Mol. Mass.:
154.1234
SMILES:
OC(=O)c1[nH]nc2COCc12
Structure:
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