Reaction Details  Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50125877
Substrate
n/a
Meas. Tech.
ChEMBL_72506 (CHEMBL685171)
IC50
16.2±n/a nM
Citation
 Guerlavais, V; Boeglin, D; Mousseaux, D; Oiry, C; Heitz, A; Deghenghi, R; Locatelli, V; Torsello, A; Ghé, C; Catapano, F; Muccioli, G; Galleyrand, JC; Fehrentz, JA; Martinez, J New active series of growth hormone secretagogues. J Med Chem 46:1191-203 (2003) [PubMed]  Article
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50125877
Synonyms:
CHEMBL281173 | [(S)-1-[(R)-2-(2-Amino-2-methyl-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-2-(1H-indol-3-yl)-ethyl]-carbamic acid ethyl ester
Type:
Small organic molecule
Emp. Form.:
C28H34N6O4
Mol. Mass.:
518.6074
SMILES:
CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N
Structure:
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