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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50167890
Substrate
n/a
Meas. Tech.
ChEMBL_303236 (CHEMBL827201)
Ki
>10000±n/a nM
Citation
 Hattori, K; Tanaka, A; Okitsu, O; Tabuchi, S; Taniguchi, K; Nishio, M; Koyama, S; Higaki, M; Seki, J; Sakane, K Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3. Bioorg Med Chem Lett 15:3091-5 (2005) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50167890
Synonyms:
CHEMBL190497 | FR-193262 | Sodium; {(R)-5-[(R)-2-(4,5-diphenyl-oxazol-2-yl)-pyrrolidin-1-yl]-5,6,7,8-tetrahydro-naphthalen-1-yloxy}-acetate
Type:
Small organic molecule
Emp. Form.:
C31H29N2O4
Mol. Mass.:
493.5735
SMILES:
[O-]C(=O)COc1cccc2[C@@H](CCCc12)N1CCC[C@@H]1c1nc(c(o1)-c1ccccc1)-c1ccccc1
Structure:
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