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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50292222
Substrate
n/a
Meas. Tech.
ChEMBL_306659 (CHEMBL831432)
IC50
160±n/a nM
Citation
 Tokunaga, T; Hume, WE; Nagamine, J; Kawamura, T; Taiji, M; Nagata, R Structure-activity relationships of the oxindole growth hormone secretagogues. Bioorg Med Chem Lett 15:1789-92 (2005) [PubMed]  Article
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50292222
Synonyms:
(S)-1-(2-Diethylamino-ethyl)-3-hydroxy-3-(2-methoxy-phenyl)-2-oxo-4-trifluoromethyl-2,3-dihydro-1H-indole-6-carboxylic acid amide | CHEMBL183916
Type:
Small organic molecule
Emp. Form.:
C23H26F3N3O4
Mol. Mass.:
465.4654
SMILES:
CCN(CC)CCN1C(=O)[C@](O)(c2c1cc(cc2C(F)(F)F)C(N)=O)c1ccccc1OC
Structure:
Search PDB for entries with ligand similarity: