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Target
Thymidine phosphorylase
Ligand
BDBM50122767
Substrate
n/a
Meas. Tech.
ChEMBL_305483 (CHEMBL830274)
IC50
21700±n/a nM
Citation
 Reigan, P; Edwards, PN; Gbaj, A; Cole, C; Barry, ST; Page, KM; Ashton, SE; Luke, RW; Douglas, KT; Stratford, IJ; Jaffar, M; Bryce, RA; Freeman, S Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs. J Med Chem 48:392-402 (2005) [PubMed]  Article
Target
Name:
Thymidine phosphorylase
Synonyms:
TYPH_ECOLI | TdRPase | Thymidine Phosphorylase (TP) | deoA | tpp | ttg
Type:
Enzyme
Mol. Mass.:
47198.54
Organism:
Escherichia coli
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM50122767
Synonyms:
5-Chloro-6-(2-nitro-imidazol-1-ylmethyl)-1H-pyrimidine-2,4-dione | CHEMBL65255
Type:
Small organic molecule
Emp. Form.:
C8H6ClN5O4
Mol. Mass.:
271.617
SMILES:
[O-][N+](=O)c1nccn1Cc1[n-]c(=[OH+])[nH]c(=O)c1Cl
Structure:
Search PDB for entries with ligand similarity: