Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50163319
Substrate
n/a
Meas. Tech.
ChEMBL_306203 (CHEMBL830161)
IC50
71000±n/a nM
Citation
 Maryanoff, BE; McComsey, DF; Costanzo, MJ; Hochman, C; Smith-Swintosky, V; Shank, RP Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem 48:1941-7 (2005) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50163319
Synonyms:
CHEMBL175644 | N-(3,4-dihydro-2H-chromen-2-ylmethyl)sulfamide | Sulfamic acid chroman-2-ylmethyl amine
Type:
Small organic molecule
Emp. Form.:
C10H14N2O3S
Mol. Mass.:
242.295
SMILES:
NS(=O)(=O)NCC1CCc2ccccc2O1
Structure:
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