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Target
Polyprenyl synthetase family protein
Ligand
BDBM50165349
Substrate
n/a
Meas. Tech.
ChEMBL_302625 (CHEMBL839917)
Ki
30±n/a nM
Citation
 Sanders, JM; Song, Y; Chan, JM; Zhang, Y; Jennings, S; Kosztowski, T; Odeh, S; Flessner, R; Schwerdtfeger, C; Kotsikorou, E; Meints, GA; Gómez, AO; González-Pacanowska, D; Raker, AM; Wang, H; van Beek, ER; Papapoulos, SE; Morita, CT; Oldfield, E Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption. J Med Chem 48:2957-63 (2005) [PubMed]  Article
Target
Name:
Polyprenyl synthetase family protein
Synonyms:
Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase
Type:
PROTEIN
Mol. Mass.:
41078.35
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_330072
Residue:
362
Sequence:
MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAEAMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVTTQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKLDANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAMVMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGSTDPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKRQK
  
Inhibitor
Name:
BDBM50165349
Synonyms:
CHEMBL363145 | hydrogen 1-hydroxy-2-(3-methoxypyridinium-1-yl)-1-phosphonoethylphosphonate
Type:
Small organic molecule
Emp. Form.:
C8H13NO8P2
Mol. Mass.:
313.1382
SMILES:
COc1ccc[n+](CC(O)(P(O)(O)=O)P(O)([O-])=O)c1
Structure:
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