Reaction Details  Report a problem with these data
Target
Melanocortin receptor 5
Ligand
BDBM50166122
Substrate
n/a
Meas. Tech.
ChEMBL_304148 (CHEMBL828129)
EC50
2.43±n/a nM
Citation
 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C N-terminal fatty acylated His-dPhe-Arg-Trp-NH(2) tetrapeptides: influence of fatty acid chain length on potency and selectivity at the mouse melanocortin receptors and human melanocytes. J Med Chem 48:3328-36 (2005) [PubMed]  Article
Target
Name:
Melanocortin receptor 5
Synonyms:
MC5R_MOUSE | Mc5r | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36966.58
Organism:
Mus musculus (Mouse)
Description:
P41149
Residue:
325
Sequence:
MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
  
Inhibitor
Name:
BDBM50166122
Synonyms:
(S)-5-Guanidino-2-{(R)-2-[(S)-3-(3H-imidazol-4-yl)-2-octadecylamino-propionylamino]-3-phenyl-propionylamino}-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide | CHEMBL364726
Type:
Small organic molecule
Emp. Form.:
C50H77N11O4
Mol. Mass.:
896.2177
SMILES:
CCCCCCCCCCCCCCCCCCN[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Structure:
Search PDB for entries with ligand similarity: