Reaction Details
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Target
Ileal sodium/bile acid cotransporter
Ligand
BDBM50172631
Substrate
n/a
Meas. Tech.
ChEMBL_321554 (CHEMBL881968)
IC50
5±n/a nM
Citation
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More Info.:
Target
Name:
Ileal sodium/bile acid cotransporter
Synonyms:
ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal bile acid transporter | Ileal bile acid transporter/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | NTCP2 | NTCP2_HUMAN | SLC10A2
Type:
Enzyme
Mol. Mass.:
37714.89
Organism:
Homo sapiens (Human)
Description:
SLC10A2
Residue:
348
Sequence:
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
Inhibitor
Name:
BDBM50172631
Synonyms:
(3S,4R,5R)-3-Butyl-7-dimethylamino-3-ethyl-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1lambda*6*-benzo[b]thiepin-4-ol | CHEMBL197639
Type:
Small organic molecule
Emp. Form.:
C24H33NO3S
Mol. Mass.:
415.589
SMILES:
CCCC[C@]1(CC)CS(=O)(=O)c2ccc(cc2[C@H]([C@H]1O)c1ccccc1)N(C)C