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Target
H(+)-exporting diphosphatase
Ligand
BDBM50138041
Substrate
n/a
Meas. Tech.
ChEMBL_321446 (CHEMBL880254)
IC50
325000±n/a nM
Citation
 Kotsikorou, E; Song, Y; Chan, JM; Faelens, S; Tovian, Z; Broderick, E; Bakalara, N; Docampo, R; Oldfield, E Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase. J Med Chem 48:6128-39 (2005) [PubMed]  Article
Target
Name:
H(+)-exporting diphosphatase
Synonyms:
Vacuolar-type proton translocating pyrophosphatase 1
Type:
PROTEIN
Mol. Mass.:
85914.14
Organism:
Trypanosoma brucei
Description:
ChEMBL_321446
Residue:
826
Sequence:
MIKMSPLLLKAAVVTACLCSLAVATTVEEQTAPKPIENATTYQQELGGRGKVDSPTAPGDAVSITSGIKVMSVTTATAIIFLASAFGFSFAMYWWYVASDIKITPGKGNIMRNAHLTDEVMRNVYVISKRVSDGANAFLFAEYRYMGIFMLGFGALLYFLLGVAMSSPQGEGKDGRPPVAVEAPWVNAAFSLYAFVIGAFTSVLAGWIGMRIAVYTNSRTAVMATVGSGGSDNDVLANGSQSRGYALAFQTAFRGGITMGFALTSIGLFALFCTVKLMQTYFGDSAERLPELFECVAAFGLGGSSVACFGRVGGGIYTKAADVGADLVGKVEKNIPEDDARNPGVIADCIGDNVGDIAGMGSDLFGSFGEATCAALVIAASSAELSADFTCMMYPLLITAGGIFVCIGTALLAATNSGVKWAEDIEPTLKHQLLVSTIGATVVLVFITAYSLPDAFTVGAVETTKWRAMVCVLCGLWSGLLIGYSTEYFTSNSYRPVQEIAESCETGAATNIIYGLSLGYISVLPPILAMAFTIYLSHHCAGLYGYALAALGILSTMSIALTIDAYGPISDNAGGIAEMAHMGHEIREITDALDAAGNTTAAIGKGFAIGSAAFVALALYGAYVSRVGISTVNLLDARVMAGLLLGAMLPYWFSALTMKSVGVAAMDMVNEIRRQFQDPAVAAGTKEPDYESCVNIATGAALQQMVAPACLVMLAPIVTGILFGRYTLAGLLPGALVSGVQVAISASNTGGAWDNAKKYIEKGGLRDKSKGKGSPQHAAAVIGDTVGDPLKDTSGPALNILVKLMAIISVVFAPVVQSKLGGLLVK
  
Inhibitor
Name:
BDBM50138041
Synonyms:
1-hydroxy-3-(methyl(2-phenoxyethyl)amino)propane-1,1-diyldiphosphonic acid | CHEMBL53982 | [1-hydroxy-3-[methyl(2-phenoxyethyl)amino]propylidene-1,1-bisphosphonate | {1-hydroxy-3-[methyl-(2-phenoxy-ethyl)-amino]-1-phosphono-propyl}-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C12H21NO8P2
Mol. Mass.:
369.2446
SMILES:
CN(CCOc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Structure:
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