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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50175514
Substrate
n/a
Meas. Tech.
ChEMBL_320761 (CHEMBL884575)
Ki
45±n/a nM
Citation
 Morphy, R; Rankovic, Z Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem 48:6523-43 (2005) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50175514
Synonyms:
1N,1N-diethyl-2-[2-hydroxy-3-(1H-4-indolyloxy)propylaminomethyl]-1-phenyl-(1S,2R)-cyclopropane-1-carboxamide | CHEMBL198072
Type:
Small organic molecule
Emp. Form.:
C26H33N3O3
Mol. Mass.:
435.5585
SMILES:
CCN(CC)C(=O)[C@]1(CC1CNCC(O)COc1cccc2[nH]ccc12)c1ccccc1
Structure:
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