Reaction Details  Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM21214
Substrate
n/a
Meas. Tech.
ChEMBL_325562 (CHEMBL860281)
Ki
125±n/a nM
Citation
 Novellino, E; Cosimelli, B; Ehlardo, M; Greco, G; Iadanza, M; Lavecchia, A; Rimoli, MG; Sala, A; Da Settimo, A; Primofiore, G; Da Settimo, F; Taliani, S; La Motta, C; Klotz, KN; Tuscano, D; Trincavelli, ML; Martini, C 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching. J Med Chem 48:8253-60 (2005) [PubMed]  Article
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM21214
Synonyms:
3-(3-chloro-1H-pyrazol-5-yl)-1,2-dihydroquinoxalin-2-one | 3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)-one | CHEMBL403521 | pyrazole-quinoxalinone, B
Type:
Small organic molecule
Emp. Form.:
C11H7ClN4O
Mol. Mass.:
246.652
SMILES:
Clc1cc(n[nH]1)-c1nc2ccccc2[nH]c1=O
Structure:
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