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Target
D(2) dopamine receptor
Ligand
BDBM50005841
Substrate
n/a
Meas. Tech.
ChEMBL_332083 (CHEMBL858805)
IC50
3900±n/a nM
Citation
 Becker, DP; Flynn, DL; Moormann, AE; Nosal, R; Villamil, CI; Loeffler, R; Gullikson, GW; Moummi, C; Yang, DC Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists. J Med Chem 49:1125-39 (2006) [PubMed]  Article
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50005841
Synonyms:
(exo) 4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-ylmethyl)-2-methoxy-benzamide | 4-amino-5-chloro-N-[(1R,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl]-2-methoxybenzamide | CHEMBL37333
Type:
Small organic molecule
Emp. Form.:
C16H22ClN3O2
Mol. Mass.:
323.818
SMILES:
COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12
Structure:
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