Reaction Details  Report a problem with these data
Target
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Ligand
BDBM50187663
Substrate
n/a
Meas. Tech.
ChEMBL_361103 (CHEMBL859169)
IC50
40000±n/a nM
Citation
 Tasdemir, D; Lack, G; Brun, R; Rüedi, P; Scapozza, L; Perozzo, R Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem 49:3345-53 (2006) [PubMed]  Article
Target
Name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Synonyms:
Fatty acid synthase
Type:
PROTEIN
Mol. Mass.:
26222.50
Organism:
Plasmodium falciparum
Description:
ChEMBL_983601
Residue:
230
Sequence:
MRFLIIHIAVIVLPFVLMIDVKRENSFFLRHSPKRLYKKADYNNMYDKIIKKQQNRIYDVSSQINQDNINGQNISFNLTFPNYDTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGLKQVSTNEPFFNGHFPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWKKPVLPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFALSK
  
Inhibitor
Name:
BDBM50187663
Synonyms:
5,7-dimethoxy-8-methyl-flavanone | CHEMBL207954
Type:
Small organic molecule
Emp. Form.:
C18H18O4
Mol. Mass.:
298.3331
SMILES:
COc1cc(OC)c2C(=O)C[C@H](Oc2c1C)c1ccccc1
Structure:
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