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Target
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Ligand
BDBM50194428
Substrate
n/a
Meas. Tech.
ChEMBL_424366 (CHEMBL911297)
IC50
19800±n/a nM
Citation
 Bachelier, A; Mayer, R; Klein, CD Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett 16:5605-9 (2006) [PubMed]  Article
Target
Name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:
EPT | Enoylpyruvate transferase | MURA_PSEAE | MurA (P. aeruginosa) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA
Type:
Protein
Mol. Mass.:
44640.67
Organism:
Pseudomonas aeruginosa (G-proteobacteria)
Description:
P. aeruginosa MurA
Residue:
421
Sequence:
MDKLIITGGNRLDGEIRISGAKNSALPILAATLLADTPVTVCNLPHLHDITTMIELFGRMGVQPIIDEKLNVEVDASSIKTLVAPYELVKTMRASILVLGPMLARFGEAEVALPGGCAIGSRPVDLHIRGLEAMGAQIEVEGGYIKAKAPAGGLRGGHFFFDTVSVTGTENLMMAAALANGRTVLQNAAREPEVVDLANCLNAMGANVQGAGSDTIVIEGVKRLGGARYDVLPDRIETGTYLVAAAATGGRVKLKDTDPTILEAVLQKLEEAGAHISTGSNWIELDMKGNRPKAVNVRTAPYPAFPTDMQAQFISMNAVAEGTGAVIETVFENRFMHVYEMNRMGAQILVEGNTAIVTGVPKLKGAPVMATDLRASASLVIAGLVAEGDTLIDRIYHIDRGYECIEEKLQLLGAKIRRVPG
  
Inhibitor
Name:
BDBM50194428
Synonyms:
CHEMBL221283 | eupatoriopicrin
Type:
Small organic molecule
Emp. Form.:
C20H26O6
Mol. Mass.:
362.4168
SMILES:
C\C1=C/[C@H]2OC(=O)C(=C)[C@@H]2[C@@H](CC(C)=CCC1)OC(=O)C(\CO)=C\CO |c:1|
Structure:
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