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Target
Sodium- and chloride-dependent taurine transporter
Ligand
BDBM50195162
Substrate
n/a
Meas. Tech.
ChEMBL_424816 (CHEMBL909060)
IC50
>30000±n/a nM
Citation
 Zhao, Z; O'Brien, JA; Lemaire, W; Williams, DL; Jacobson, MA; Sur, C; Pettibone, DJ; Tiller, PR; Smith, S; Hartman, GD; Wolkenberg, SE; Lindsley, CW Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides. Bioorg Med Chem Lett 16:5968-72 (2006) [PubMed]  Article
Target
Name:
Sodium- and chloride-dependent taurine transporter
Synonyms:
SC6A6_HUMAN | SLC6A6
Type:
PROTEIN
Mol. Mass.:
69833.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_543463
Residue:
620
Sequence:
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNSRTVMNGALVKPTHIIVETMM
  
Inhibitor
Name:
BDBM50195162
Synonyms:
2,4-dichloro-N-((4-(1-methylpiperazine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamide | CHEMBL436976
Type:
Small organic molecule
Emp. Form.:
C22H32Cl2N4O4S
Mol. Mass.:
519.485
SMILES:
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCN(C)CC1
Structure:
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