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Target
L-selectin
Ligand
BDBM50205403
Substrate
n/a
Meas. Tech.
ChEMBL_428319 (CHEMBL917097)
IC50
1600±n/a nM
Citation
 Kranich, R; Busemann, AS; Bock, D; Schroeter-Maas, S; Beyer, D; Heinemann, B; Meyer, M; Schierhorn, K; Zahlten, R; Wolff, G; Aydt, EM Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem 50:1101-15 (2007) [PubMed]  Article
Target
Name:
L-selectin
Synonyms:
LNHR | LYAM1 | LYAM1_HUMAN | Leukocyte adhesion molecule-1 | SELL | Selectin
Type:
PROTEIN
Mol. Mass.:
42187.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_200000
Residue:
372
Sequence:
MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKRSMNDPY
  
Inhibitor
Name:
BDBM50205403
Synonyms:
5-{2-[(2'3',4'-hydroxy-biphenyl-3-carbonyl)-amino]-phenyl}-thiophene-2-carboxylic acid | CHEMBL373592
Type:
Small organic molecule
Emp. Form.:
C24H17NO6S
Mol. Mass.:
447.46
SMILES:
OC(=O)c1ccc(s1)-c1ccccc1NC(=O)c1cccc(c1)-c1ccc(O)c(O)c1O
Structure:
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