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Target
Protein arginine N-methyltransferase 1 [11-371]
Ligand
BDBM29278
Substrate
n/a
Meas. Tech.
ChEMBL_428527 (CHEMBL919884)
IC50
>510000±n/a nM
Citation
 Ragno, R; Simeoni, S; Castellano, S; Vicidomini, C; Mai, A; Caroli, A; Tramontano, A; Bonaccini, C; Trojer, P; Bauer, I; Brosch, G; Sbardella, G Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations. J Med Chem 50:1241-53 (2007) [PubMed]  Article
Target
Name:
Protein arginine N-methyltransferase 1 [11-371]
Synonyms:
ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:
Protein
Mol. Mass.:
41506.52
Organism:
Homo sapiens (Human)
Description:
Q99873[11-371]
Residue:
361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM29278
Synonyms:
CHEMBL310671 | Garantose | SAC | Saccharimide | Saccharin
Type:
Small organic molecule
Emp. Form.:
C7H5NO3S
Mol. Mass.:
183.185
SMILES:
O=C1NS(=O)(=O)c2ccccc12
Structure:
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