Reaction Details  Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM50202275
Substrate
n/a
Meas. Tech.
ChEMBL_441637 (CHEMBL891868)
Ki
13500±n/a nM
Citation
 Xing, C; Wang, L; Tang, X; Sham, YY Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1. Bioorg Med Chem 15:2167-76 (2007) [PubMed]  Article
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50202275
Synonyms:
2-[5-(1-phenylbutylidene)-4-oxo-2-thioxothiazolidin-3-yl]-4-methylpentanoic acid | CHEMBL242126
Type:
Small organic molecule
Emp. Form.:
C19H23NO3S2
Mol. Mass.:
377.521
SMILES:
CCC\C(=C1\SC(=S)N([C@@H](CC(C)C)C(O)=O)C1=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: