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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50048522
Substrate
n/a
Meas. Tech.
ChEMBL_443211 (CHEMBL893459)
IC50
242000±n/a nM
Citation
 Shrestha, S; Bhattarai, BR; Chang, KJ; Lee, KH; Cho, H Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity. Bioorg Med Chem Lett 17:2760-4 (2007) [PubMed]  Article
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50048522
Synonyms:
5,5'-methylenebis(3-chloro-2-hydroxybenzoic acid) | 5-(3-carboxy-5-chloro-4-hydroxybenzyl)-3-chloro-2-hydroxybenzoic acid | CHEMBL116347
Type:
Small organic molecule
Emp. Form.:
C15H10Cl2O6
Mol. Mass.:
357.142
SMILES:
OC(=O)c1cc(Cc2cc(Cl)c(O)c(c2)C(O)=O)cc(Cl)c1O
Structure:
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