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Target
Trans-2-enoyl-ACP reductase II
Ligand
BDBM50223358
Substrate
n/a
Meas. Tech.
ChEMBL_450119 (CHEMBL900394)
IC50
3400±n/a nM
Citation
 Ozawa, T; Kitagawa, H; Yamamoto, Y; Takahata, S; Iida, M; Osaki, Y; Yamada, K Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Bioorg Med Chem 15:7325-36 (2007) [PubMed]  Article
Target
Name:
Trans-2-enoyl-ACP reductase II
Synonyms:
Enoyl-ACP Reductase (FabK) | FabK | NADH-dependent, FAD-containing enoyl-ACP | trans-2-enoyl-ACP reductase II
Type:
Enzyme
Mol. Mass.:
34170.89
Organism:
Streptococcus pneumoniae
Description:
n/a
Residue:
324
Sequence:
MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKYMERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATAISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDTTISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVDGGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWTGVVRND
  
Inhibitor
Name:
BDBM50223358
Synonyms:
1-(6-(methylsulfonyl)benzo[d]thiazol-2-yl)-3-((5-(pyridin-2-yl)thiophen-2-yl)methyl)urea | CHEMBL237449
Type:
Small organic molecule
Emp. Form.:
C19H16N4O3S3
Mol. Mass.:
444.55
SMILES:
CS(=O)(=O)c1ccc2nc(NC(=O)NCc3ccc(s3)-c3ccccn3)sc2c1
Structure:
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