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Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Ligand
BDBM50223355
Substrate
n/a
Meas. Tech.
ChEMBL_450121 (CHEMBL900393)
IC50
>32000±n/a nM
Citation
 Ozawa, T; Kitagawa, H; Yamamoto, Y; Takahata, S; Iida, M; Osaki, Y; Yamada, K Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Bioorg Med Chem 15:7325-36 (2007) [PubMed]  Article
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Synonyms:
Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI
Type:
Enzyme
Mol. Mass.:
27861.12
Organism:
Escherichia coli
Description:
n/a
Residue:
262
Sequence:
MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK
  
Inhibitor
Name:
BDBM50223355
Synonyms:
1-((1H-benzo[d]imidazol-2-yl)methyl)-3-(6-cyanobenzo[d]thiazol-2-yl)urea | CHEMBL237836
Type:
Small organic molecule
Emp. Form.:
C17H12N6OS
Mol. Mass.:
348.382
SMILES:
O=C(NCc1nc2ccccc2[nH]1)Nc1nc2ccc(cc2s1)C#N
Structure:
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