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Target
Collagenase 3
Ligand
BDBM50225411
Substrate
n/a
Meas. Tech.
ChEMBL_451368 (CHEMBL901571)
IC50
0.9±n/a nM
Citation
 Wagner, S; Breyholz, HJ; Law, MP; Faust, A; Höltke, C; Schröer, S; Haufe, G; Levkau, B; Schober, O; Schäfers, M; Kopka, K Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem 50:5752-64 (2007) [PubMed]  Article
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM50225411
Synonyms:
(R)-2-(N-((6-fluoropyridin-3-yl)methyl)-4-methoxyphenylsulphonamido)-N-hydroxy-3-methylbutanamide | CHEMBL235095
Type:
Small organic molecule
Emp. Form.:
C18H22FN3O5S
Mol. Mass.:
411.448
SMILES:
COc1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)nc1)[C@H](C(C)C)C(=O)NO
Structure:
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