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Target
Neutrophil collagenase
Ligand
BDBM50225399
Substrate
n/a
Meas. Tech.
ChEMBL_451366 (CHEMBL901569)
IC50
105±n/a nM
Citation
 Wagner, S; Breyholz, HJ; Law, MP; Faust, A; Höltke, C; Schröer, S; Haufe, G; Levkau, B; Schober, O; Schäfers, M; Kopka, K Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem 50:5752-64 (2007) [PubMed]  Article
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50225399
Synonyms:
(R)-2-(N-benzyl-4-(dimethylamino)phenylsulphonamido)-Nhydroxy-3-methylbutanamide | CHEMBL235916
Type:
Small organic molecule
Emp. Form.:
C20H27N3O4S
Mol. Mass.:
405.511
SMILES:
CC(C)[C@@H](N(Cc1ccccc1)S(=O)(=O)c1ccc(cc1)N(C)C)C(=O)NO
Structure:
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