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Target
Adenosine receptor A2a
Ligand
BDBM50225883
Substrate
n/a
Meas. Tech.
ChEMBL_451678 (CHEMBL901887)
Ki
7800±n/a nM
Citation
 Ashton, TD; Aumann, KM; Baker, SP; Schiesser, CH; Scammells, PJ Structure-activity relationships of adenosines with heterocyclic N6-substituents. Bioorg Med Chem Lett 17:6779-84 (2007) [PubMed]  Article
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50225883
Synonyms:
CHEMBL391031 | endo-(2R,3R,4S,5R)-2-(6-(7-aza-bicyclo[2.2.1]heptan-2-ylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Type:
Small organic molecule
Emp. Form.:
C16H22N6O4
Mol. Mass.:
362.3837
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CC4CCC3N4)ncnc12 |w:17.23,20.20,15.15,TEB:14:15:21:18.19|
Structure:
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