Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50228923
Substrate
n/a
Meas. Tech.
ChEMBL_461701 (CHEMBL927722)
Ki
12±n/a nM
Citation
Varnes, JG; Wacker, DA; Pinto, DJ; Orwat, MJ; Theroff, JP; Wells, B; Galemo, RA; Luettgen, JM; Knabb, RM; Bai, S; He, K; Lam, PY; Wexler, RR Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors. Bioorg Med Chem Lett 18:749-54 (2008) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50228923
Synonyms:
4'-{2-[2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-2-oxo-ethyl}-biphenyl-2-sulfonic acid amide | CHEMBL252649
Type:
Small organic molecule
Emp. Form.:
C25H20F3N3O4S
Mol. Mass.:
515.504
SMILES:
COc1ccc(cc1)-n1nc(cc1C(=O)Cc1ccc(cc1)-c1ccccc1S(N)(=O)=O)C(F)(F)F