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Target
Intermediate conductance calcium-activated potassium channel protein 4
Ligand
BDBM50371381
Substrate
n/a
Meas. Tech.
ChEMBL_463302 (CHEMBL948111)
IC50
4300±n/a nM
Citation
 McNaughton-Smith, GA; Burns, JF; Stocker, JW; Rigdon, GC; Creech, C; Arrington, S; Shelton, T; de Franceschi, L Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem 51:976-82 (2008) [PubMed]  Article
Target
Name:
Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:
IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:
PROTEIN
Mol. Mass.:
47723.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361891
Residue:
427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
  
Inhibitor
Name:
BDBM50371381
Synonyms:
CHEMBL271167
Type:
Small organic molecule
Emp. Form.:
C22H19NO
Mol. Mass.:
313.3924
SMILES:
C1CN=C(O1)C(c1ccccc1)(c1ccccc1)c1ccccc1 |c:2|
Structure:
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