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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50371614
Substrate
n/a
Meas. Tech.
ChEMBL_463794 (CHEMBL932183)
IC50
41600±n/a nM
Citation
 Tang, G; Nikolovska-Coleska, Z; Qiu, S; Yang, CY; Guo, J; Wang, S Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins. J Med Chem 51:717-20 (2008) [PubMed]  Article
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50371614
Synonyms:
CHEMBL269836
Type:
Small organic molecule
Emp. Form.:
C16H16O4
Mol. Mass.:
272.2958
SMILES:
CC(C)c1cc(C(=O)c2ccccc2)c(O)c(O)c1O
Structure:
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