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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50371793
Substrate
n/a
Meas. Tech.
ChEMBL_464067 (CHEMBL949060)
IC50
7±n/a nM
Citation
 Walters, I; Austin, C; Austin, R; Bonnert, R; Cage, P; Christie, M; Ebden, M; Gardiner, S; Grahames, C; Hill, S; Hunt, F; Jewell, R; Lewis, S; Martin, I; David Nicholls, na; David Robinson, na Evaluation of a series of bicyclic CXCR2 antagonists. Bioorg Med Chem Lett 18:798-803 (2008) [PubMed]
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50371793
Synonyms:
CHEMBL271703
Type:
Small organic molecule
Emp. Form.:
C16H16F2N6OS
Mol. Mass.:
378.4
SMILES:
C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2nc(N)cnc12
Structure:
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