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Target
Adenosylhomocysteinase
Ligand
BDBM50135289
Substrate
n/a
Meas. Tech.
ChEMBL_466720 (CHEMBL937441)
IC50
63000±n/a nM
Citation
 Ando, T; Iwata, M; Zulfiqar, F; Miyamoto, T; Nakanishi, M; Kitade, Y Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. Bioorg Med Chem 16:3809-15 (2008) [PubMed]  Article
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50135289
Synonyms:
(1S,2R,3S,4R)-4-(6-Amino-2-fluoro-purin-9-yl)-cyclopentane-1,2,3-triol | (1S,2R,3S,4R)-4-(6-amino-2-fluoro-9H-purin-9-yl)cyclopentane-1,2,3-triol | 2-fluoronoraristeromycin | CHEMBL129469
Type:
Small organic molecule
Emp. Form.:
C10H12FN5O3
Mol. Mass.:
269.2324
SMILES:
Nc1nc(F)nc2n(cnc12)[C@@H]1C[C@H](O)[C@@H](O)[C@H]1O
Structure:
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