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Target
P2Y purinoceptor 12
Ligand
BDBM50374569
Substrate
n/a
Meas. Tech.
ChEMBL_469575 (CHEMBL933022)
IC50
2700±n/a nM
Citation
 Douglass, JG; deCamp, JB; Fulcher, EH; Jones, W; Mahanty, S; Morgan, A; Smirnov, D; Boyer, JL; Watson, PS Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation. Bioorg Med Chem Lett 18:2167-71 (2008) [PubMed]  Article
Target
Name:
P2Y purinoceptor 12
Synonyms:
ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:
Enzyme
Mol. Mass.:
39458.48
Organism:
Homo sapiens (Human)
Description:
Q9H244
Residue:
342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
  
Inhibitor
Name:
BDBM50374569
Synonyms:
CHEMBL271643
Type:
Small organic molecule
Emp. Form.:
C27H31N7O6
Mol. Mass.:
549.5783
SMILES:
CCNC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CNCC2CC2C(O)=O)[C@H]2O[C@@H](O[C@@H]12)\C=C\c1ccccc1 |w:23.26,21.22|
Structure:
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