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Target
cGMP-dependent protein kinase
Ligand
BDBM50374580
Substrate
n/a
Meas. Tech.
ChEMBL_469577 (CHEMBL934050)
IC50
0.34±n/a nM
Citation
 Liang, GB; Qian, X; Feng, D; Fisher, M; Crumley, T; Darkin-Rattray, SJ; Dulski, PM; Gurnett, A; Leavitt, PS; Liberator, PA; Misura, AS; Samaras, S; Tamas, T; Schmatz, DM; Wyvratt, M; Biftu, T N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents. Bioorg Med Chem Lett 18:2019-22 (2008) [PubMed]  Article
Target
Name:
cGMP-dependent protein kinase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
112911.27
Organism:
Eimeria tenella
Description:
ChEMBL_469577
Residue:
1003
Sequence:
MGACSSKAQHQTRDPEPREQQAAQEQKSTGPSGAPNDAPAPAEAERKMSGSSATAPKGEMPTASTGTPEQQQQQQQQQQQQQEQQQHPEHQQSEKQQQHGEEQQQERKPSQQQQNEEAAAPHKHGGERKVQKAIKQQEDTQAEDARLLGHLEKREKTPSDLSLIRDSLSTNLVCSSLNDAEVEALANAVEFFTFKKGDVVTKQGESGSYFFIVHSGEFEVIVNDKVVNKILTGQAFGEISLIHNSARTATIKTLSEDAALWGVQRQVFRETLKQLSSRNFAENRQFLASVKFFEMLTEAQKNVITNALVVQSFQPGQAIVKEGEKGDVLYILKSGKALVSIKNKEVRVLQRGEYFGERALLYDEPRSATITAEEPTVCVSIGRDLLDRVLGNLQHVLFRNIMLEALQQSKVFASFPTEQLSRLIGSVVVKDYPENYIILDRENRTRASASALFSAQGVRFFFVLEGEVSVFAYKDKSSSSSSSSSSSSSSSSAEGEMELHLIDTLKRGQAFGDEYVLSPNKPFAHCVKSNGPTKLALLTASALTATLGGQDIDETLDYNNKLAITKKMYIFRYLSEQQTQTLIKAFKTVRYTQGESIIREGEIGSRFFIIKLGEVVILKGEKRVRTLGRHDYFGERALLHDERRSATVAANSPEVDLWVVDKDVFLQIVKGPMLTHLEERIRMQDTKVEFKDLNVVRVVGRGTFGTVKLVQHIPTQMRYALKCVSRKSVVALNQQDHIRLEREIMAENDHPFIIRLVRTFRDKEFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHERNIAYRDLKPENILLDSQGYVKLIDFGCAKKMQGRAYTLVGTPHYMAPEVILGKGYTLTADTWAFGVCLYEFMCGPLPFGNDAEDQLEIFRDILAGKLIFPHYVTDQDAINLMKRLLCRLPEVRIGCSINGYKDIKEHAFFSDFDWDRLAGRDLSPPLLPKGEIYAEDAEEGGLDIEEDEGIELEDEYEWDKDF
  
Inhibitor
Name:
BDBM50374580
Synonyms:
CHEMBL271638
Type:
Small organic molecule
Emp. Form.:
C26H31FN4O
Mol. Mass.:
434.5489
SMILES:
CN1C[C@H](O)C[C@H]1CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Structure:
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