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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50375806
Substrate
n/a
Meas. Tech.
ChEMBL_474267 (CHEMBL935072)
IC50
6±n/a nM
Citation
 Chen, MH; Fitzgerald, P; Singh, SB; O'Neill, EA; Schwartz, CD; Thompson, CM; O'Keefe, SJ; Zaller, DM; Doherty, JB Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors. Bioorg Med Chem Lett 18:2222-6 (2008) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50375806
Synonyms:
CHEMBL405713
Type:
Small organic molecule
Emp. Form.:
C21H12Cl3NO
Mol. Mass.:
400.685
SMILES:
Clc1ccccc1-c1cccc2n(-c3c(Cl)cccc3Cl)c(=O)ccc12 |(.21,-16.12,;-1.12,-16.9,;-1.12,-18.44,;-2.46,-19.21,;-3.8,-18.44,;-3.79,-16.9,;-2.45,-16.13,;-2.45,-14.59,;-1.12,-13.82,;-1.13,-12.28,;-2.46,-11.52,;-3.78,-12.28,;-5.11,-11.5,;-5.11,-9.96,;-6.43,-9.19,;-7.77,-9.97,;-6.44,-7.66,;-5.1,-6.88,;-3.76,-7.65,;-3.76,-9.19,;-2.43,-9.96,;-6.44,-12.28,;-7.78,-11.52,;-6.44,-13.83,;-5.11,-14.59,;-3.78,-13.82,)|
Structure:
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