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Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Ligand
BDBM50326328
Substrate
n/a
Meas. Tech.
ChEMBL_479301 (CHEMBL933673)
IC50
7000±n/a nM
Citation
 Tipparaju, SK; Joyasawal, S; Forrester, S; Mulhearn, DC; Pegan, S; Johnson, ME; Mesecar, AD; Kozikowski, AP Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase. Bioorg Med Chem Lett 18:3565-9 (2008) [PubMed]  Article
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Synonyms:
CSI15 | Cold shock-induced protein 15 | ENR | Enoyl-[acyl-carrier-protein] reductase [NADH] | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI | FABI_BACSU | NADH-dependent enoyl-ACP reductase | VEG241 | Vegetative protein 241 | fabI | yjbW
Type:
PROTEIN
Mol. Mass.:
27870.90
Organism:
Bacillus subtilis (strain 168)
Description:
ChEMBL_479301
Residue:
258
Sequence:
MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGERLEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEELVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNVMGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPLRRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR
  
Inhibitor
Name:
BDBM50326328
Synonyms:
4-((4-(benzyloxy)-2-oxopyridin-1(2H)-yl)methyl)-3-chlorobenzonitrile | CHEMBL407894
Type:
Small organic molecule
Emp. Form.:
C20H15ClN2O2
Mol. Mass.:
350.798
SMILES:
Clc1cc(ccc1Cn1ccc(OCc2ccccc2)cc1=O)C#N
Structure:
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