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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50377238
Substrate
n/a
Meas. Tech.
ChEMBL_479408 (CHEMBL928210)
IC50
279±n/a nM
Citation
 Lum, C; Kahl, J; Kessler, L; Kucharski, J; Lundström, J; Miller, S; Nakanishi, H; Pei, Y; Pryor, K; Roberts, E; Sebo, L; Sullivan, R; Urban, J; Wang, Z 2,5-Diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3). Bioorg Med Chem Lett 18:3578-81 (2008) [PubMed]  Article
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50377238
Synonyms:
CHEMBL255948
Type:
Small organic molecule
Emp. Form.:
C16H18N6O
Mol. Mass.:
310.3537
SMILES:
O[C@H]1CC[C@@H](CC1)Nc1ncc2nnn(-c3ccccc3)c2n1 |wU:4.7,wD:1.0,(22.09,-29.69,;22.09,-28.15,;23.43,-27.38,;23.43,-25.84,;22.1,-25.08,;20.76,-25.84,;20.76,-27.38,;22.09,-23.54,;20.76,-22.77,;20.75,-21.21,;19.41,-20.45,;18.08,-21.23,;16.61,-20.76,;15.71,-22.01,;16.62,-23.25,;16.15,-24.71,;14.64,-25.03,;14.17,-26.5,;15.21,-27.64,;16.72,-27.31,;17.19,-25.84,;18.09,-22.77,;19.42,-23.54,)|
Structure:
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