Reaction Details  Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50165062
Substrate
n/a
Meas. Tech.
ChEMBL_479714 (CHEMBL921474)
Ki
1680±n/a nM
Citation
 Gillespie, RJ; Cliffe, IA; Dawson, CE; Dourish, CT; Gaur, S; Jordan, AM; Knight, AR; Lerpiniere, J; Misra, A; Pratt, RM; Roffey, J; Stratton, GC; Upton, R; Weiss, SM; Williamson, DS Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. Bioorg Med Chem Lett 18:2924-9 (2008) [PubMed]  Article
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50165062
Synonyms:
6-Furan-2-yl-9-(3-methoxy-benzyl)-9H-purin-2-ylamine | 9-(3-methoxybenzyl)-6-(furan-2-yl)-9H-purin-2-amine | CHEMBL371436
Type:
Small organic molecule
Emp. Form.:
C17H15N5O2
Mol. Mass.:
321.3333
SMILES:
COc1cccc(Cn2cnc3c(nc(N)nc23)-c2ccco2)c1
Structure:
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