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Target
Urotensin-2 receptor
Ligand
BDBM50241425
Substrate
n/a
Meas. Tech.
ChEMBL_479798 (CHEMBL930368)
IC50
631±n/a nM
Citation
 Jin, J; Wang, Y; Wang, F; Shi, D; Erhard, KF; Wu, Z; Guida, BF; Lawrence, SK; Behm, DJ; Disa, J; Vaidya, KS; Evans, C; McMillan, LJ; Rivero, RA; Neeb, MJ; Douglas, SA 2-Aminomethyl piperidines as novel urotensin-II receptor antagonists. Bioorg Med Chem Lett 18:2860-4 (2008) [PubMed]  Article
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | GPR14 | UR-II-R | UR2R_HUMAN | UTS2R | Urotensin II receptor | Urotensin-II
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42159.71
Organism:
Homo sapiens (Human)
Description:
Urotensin-II UTS2R HUMAN::Q9UKP6
Residue:
389
Sequence:
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
  
Inhibitor
Name:
BDBM50241425
Synonyms:
2-((3,4-dichlorophenyl)(methyl)amino)-1-(2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)ethanone | CHEMBL254154
Type:
Small organic molecule
Emp. Form.:
C19H27Cl2N3O
Mol. Mass.:
384.343
SMILES:
CN(CC(=O)N1CCCCC1CN1CCCC1)c1ccc(Cl)c(Cl)c1
Structure:
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