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Target
M-phase inducer phosphatase 2
Ligand
BDBM50208827
Substrate
n/a
Meas. Tech.
ChEMBL_535776 (CHEMBL991541)
IC50
3770±n/a nM
Citation
 Braud, E; Goddard, ML; Kolb, S; Brun, MP; Mondésert, O; Quaranta, M; Gresh, N; Ducommun, B; Garbay, C Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem 16:9040-9 (2008) [PubMed]  Article
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50208827
Synonyms:
2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione | CHEMBL429095 | N1786 (NSC95397) | NSC 9539 | NSC 95397 | NSC-95397 | cid_262093
Type:
Small organic molecule
Emp. Form.:
C14H14O4S2
Mol. Mass.:
310.389
SMILES:
OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O |c:4|
Structure:
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