Reaction Details Report a problem with these data
Target
Insulin receptor
Ligand
BDBM50253167
Substrate
n/a
Meas. Tech.
ChEMBL_538724 (CHEMBL1035035)
EC50
73000±n/a nM
Citation
Lum, RT; Cheng, M; Cristobal, CP; Goldfine, ID; Evans, JL; Keck, JG; Macsata, RW; Manchem, VP; Matsumoto, Y; Park, SJ; Rao, SS; Robinson, L; Shi, S; Spevak, WR; Schow, SR Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators. J Med Chem 51:6173-87 (2008) [PubMed] Article
More Info.:
Target
Name:
Insulin receptor
Synonyms:
CD_antigen=CD220 | INSR_MOUSE | IR | Insr | Insulin receptor subunit alpha | Insulin receptor subunit beta
Type:
PROTEIN
Mol. Mass.:
155593.32
Organism:
Mus musculus
Description:
ChEMBL_305383
Residue:
1372
Sequence:
MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS
Inhibitor
Name:
BDBM50253167
Synonyms:
1,3-bis(5-hydroxy-7-{[3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]sulfamoyl}naphthalen-2-yl)urea | CHEMBL455114
Type:
Small organic molecule
Emp. Form.:
C35H26N12O7S2
Mol. Mass.:
790.787
SMILES:
Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(=O)(=O)Nc3cccc(c3)-n3cnnn3)ccc12)S(=O)(=O)Nc1cccc(c1)-n1cnnn1