Reaction Details  Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50252898
Substrate
n/a
Meas. Tech.
ChEMBL_539391 (CHEMBL1027275)
EC50
0.45±n/a nM
Citation
 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity. J Med Chem 51:5585-93 (2008) [PubMed]  Article
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R_MOUSE | Mc4r
Type:
PROTEIN
Mol. Mass.:
36964.43
Organism:
Mus musculus
Description:
ChEMBL_1498850
Residue:
332
Sequence:
MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY
  
Inhibitor
Name:
BDBM50252898
Synonyms:
Ac-His-DPhe(pF)-Arg-Trp-NH2 | CHEMBL444219
Type:
Small organic molecule
Emp. Form.:
C34H42FN11O5
Mol. Mass.:
703.7664
SMILES:
CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r,wU:4.3,14.14,26.27,wD:37.38,(-9.03,-31.03,;-9.03,-32.57,;-10.36,-33.34,;-7.69,-33.35,;-6.36,-32.58,;-6.36,-31.03,;-5.02,-30.26,;-3.62,-30.89,;-2.58,-29.75,;-3.35,-28.41,;-4.86,-28.73,;-5.02,-33.35,;-5.02,-34.89,;-3.69,-32.58,;-2.36,-33.35,;-2.36,-34.88,;-1.03,-35.66,;.31,-34.89,;1.65,-35.66,;1.64,-37.2,;2.97,-37.97,;.31,-37.97,;-1.02,-37.2,;-1.03,-32.58,;-1.03,-31.04,;.31,-33.34,;1.65,-32.58,;1.65,-31.04,;2.98,-30.27,;2.98,-28.73,;4.32,-27.96,;4.32,-26.43,;2.99,-25.66,;5.66,-25.65,;2.98,-33.35,;2.98,-34.9,;4.32,-32.58,;5.65,-33.35,;5.65,-34.9,;6.98,-35.67,;8.39,-35.04,;9.42,-36.19,;8.65,-37.52,;9.12,-38.99,;8.09,-40.13,;6.58,-39.81,;6.11,-38.34,;7.14,-37.2,;6.98,-32.59,;8.32,-33.36,;6.98,-31.05,)|
Structure:
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