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Target
Carbonic anhydrase 2
Ligand
BDBM10876
Substrate
n/a
Meas. Tech.
ChEMBL_515850 (CHEMBL993109)
Ki
80±n/a nM
Citation
 Isik, S; Kockar, F; Aydin, M; Arslan, O; Guler, OO; Innocenti, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates. Bioorg Med Chem 17:1158-63 (2009) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM10876
Synonyms:
4-(hydroxymethyl)benzene-1-sulfonamide | CHEMBL6919 | JMC522226 Compound 20 | JMC523116 Compound 20 | aromatic/heteroaromatic sulfonamide 21
Type:
Small organic molecule
Emp. Form.:
C7H9NO3S
Mol. Mass.:
187.216
SMILES:
NS(=O)(=O)c1ccc(CO)cc1
Structure:
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