Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50248167
Substrate
n/a
Meas. Tech.
ChEMBL_565855 (CHEMBL959278)
Ki
72.5±n/a nM
Citation
 Crocetti, L; Maresca, A; Temperini, C; Hall, RA; Scozzafava, A; Mühlschlegel, FA; Supuran, CT A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg Med Chem Lett 19:1371-5 (2009) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50248167
Synonyms:
2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide | 2-(thiazol-4-yl)-1H-benzo[d]imidazole-5-sulfonamide | CHEMBL455271
Type:
Small organic molecule
Emp. Form.:
C10H8N4O2S2
Mol. Mass.:
280.326
SMILES:
NS(=O)(=O)c1ccc2nc([nH]c2c1)-c1cscn1
Structure:
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