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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50296714
Substrate
n/a
Meas. Tech.
ChEMBL_582484 (CHEMBL1058161)
Ki
212±n/a nM
Citation
 O'Donnell, CJ; Peng, L; O'Neill, BT; Arnold, EP; Mather, RJ; Sands, SB; Shrikhande, A; Lebel, LA; Spracklin, DK; Nedza, FM Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 19:4747-51 (2009) [PubMed]  Article
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50296714
Synonyms:
4-phenoxyphenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate | CHEMBL550927
Type:
Small organic molecule
Emp. Form.:
C20H22N2O3
Mol. Mass.:
338.4003
SMILES:
O=C(Oc1ccc(Oc2ccccc2)cc1)N1CCN2CCC1CC2 |TLB:1:16:21.20:23.24,(21.87,-16.87,;22.15,-18.45,;23.66,-19,;24.89,-17.96,;26.4,-18.52,;27.62,-17.48,;27.34,-15.9,;28.52,-14.91,;29.97,-15.43,;30.23,-16.94,;31.68,-17.47,;32.86,-16.47,;32.58,-14.95,;31.13,-14.43,;25.82,-15.35,;24.6,-16.39,;20.93,-19.48,;21.3,-21.02,;20.26,-20.26,;18.82,-20.34,;18.74,-18.56,;19.39,-17.36,;19.46,-18.84,;18.11,-19.57,;17.79,-21.07,)|
Structure:
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