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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50296719
Substrate
n/a
Meas. Tech.
ChEMBL_582484 (CHEMBL1058161)
Ki
79±n/a nM
Citation
O'Donnell, CJ; Peng, L; O'Neill, BT; Arnold, EP; Mather, RJ; Sands, SB; Shrikhande, A; Lebel, LA; Spracklin, DK; Nedza, FM Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 19:4747-51 (2009) [PubMed] Article
More Info.:
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Inhibitor
Name:
BDBM50296719
Synonyms:
3-methoxyphenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate | CHEMBL558127
Type:
Small organic molecule
Emp. Form.:
C15H20N2O3
Mol. Mass.:
276.3309
SMILES:
COc1cccc(OC(=O)N2CCN3CCC2CC3)c1 |TLB:8:10:15.14:17.18,(1.83,-7.16,;1.55,-5.64,;.11,-5.11,;-.17,-3.58,;-1.63,-3.06,;-2.81,-4.06,;-2.53,-5.57,;-3.7,-6.56,;-5.16,-6.04,;-5.43,-4.52,;-6.34,-7.03,;-5.98,-8.51,;-6.98,-7.79,;-8.36,-7.85,;-8.44,-6.14,;-7.82,-5,;-7.75,-6.41,;-9.05,-7.12,;-9.36,-8.56,;-1.08,-6.1,)|