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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50296731
Substrate
n/a
Meas. Tech.
ChEMBL_582484 (CHEMBL1058161)
Ki
>4720±n/a nM
Citation
 O'Donnell, CJ; Peng, L; O'Neill, BT; Arnold, EP; Mather, RJ; Sands, SB; Shrikhande, A; Lebel, LA; Spracklin, DK; Nedza, FM Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 19:4747-51 (2009) [PubMed]  Article
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50296731
Synonyms:
4-(4-bromophenylsulfonyl)-1,4-diazabicyclo[3.2.2]nonane | CHEMBL559598
Type:
Small organic molecule
Emp. Form.:
C13H17BrN2O2S
Mol. Mass.:
345.255
SMILES:
Brc1ccc(cc1)S(=O)(=O)N1CCN2CCC1CC2 |TLB:7:10:15.14:17.18,(15.02,-35.01,;13.57,-34.49,;12.39,-35.48,;10.94,-34.96,;10.67,-33.44,;11.84,-32.44,;13.29,-32.96,;9.22,-32.91,;8.12,-31.81,;10.31,-31.8,;8.04,-33.91,;8.4,-35.38,;7.4,-34.66,;6.01,-34.73,;5.94,-33.02,;6.56,-31.87,;6.62,-33.29,;5.32,-33.99,;5.02,-35.44,)|
Structure:
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